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Neuroscience and motor control group at the Univ of Coruña and Experimental Neurophysiology group at thel Hospital de Parapléjicos de Toledo, have a broad experience on neuromodulation and Central Nervous System physiology. The two groups have joined their knowledge to launch the project "Effect of static magnetic fields of moderate intensity in models of epilepsy and Dravet syndrome".
Static magnetic fields (0.5 Tesla intensity) have shown their effectiveness, in different studies, to reduce cortical excitability, so in this project we consider its application to reduce excitability in epilepsy. In pharmacological model of epilepsy in rats, and in a case of lesion induced focal epilepsy in primate magnetic fields reduced the intensity and number of seizures (Rivadulla et al, Scientific Reports 2018). We are currently development, preliminary studies in a Dravet mouse model (in collaboration with Manuel Álvarez Dolado, director of the cell therapy group in neuropathologies at CABIMER) showing similar results. These are treatments in the acute phase of the seizures, but we are also studying the possible application of a preventive treatment, testing if the application of the magnetic fields for several days before the seizures is able to decrease the intensity or frequency of those.